Human IgG/FcγR Interactions Are Modulated by Streptococcal IgG Glycan Hydrolysis
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چکیده
منابع مشابه
Human IgG/FcγR Interactions Are Modulated by Streptococcal IgG Glycan Hydrolysis
BACKGROUND The human pathogen Streptococcus pyogenes produces an endoglycosidase, EndoS that hydrolyzes the chitobiose core of the asparagine-linked glycan on the heavy chain of human IgG. IgG-binding to Fc gamma receptors (Fc gamma R) on leukocytes triggers effector functions including phagocytosis, oxidative burst and the release of inflammatory mediators. The interactions between Fc gamma R ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2008
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0001413